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Related Experiment Video

Updated: Apr 25, 2026

Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples

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Published on: July 28, 2016

Human lysyl oxidase-like 2.

Hee-Jung Moon¹, Joel Finney¹, Trey Ronnebaum¹

¹Department of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.

Bioorganic Chemistry

|August 23, 2014

Summary

Lysyl oxidase like-2 (LOXL2) is an enzyme involved in extracellular matrix crosslinking and cell signaling. Its dysregulation is linked to diseases like cancer and fibrosis.

Keywords:

Cell signaling Extracellular matrix Lysine tyrosylquinone (LTQ)Lysyl oxidase family Lysyl oxidase like-2 Tumor metastasis/invasion

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Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

Lysyl oxidase like-2 (LOXL2) is part of the lysyl oxidase (LOX) family of enzymes.
LOXL2 utilizes copper (Cu2+) and lysine tyrosylquinone (LTQ) for its amine oxidase activity.
LOXL2 is hypothesized to function in the extracellular matrix (ECM), similar to LOX, by crosslinking collagen and elastin.

Purpose of the Study:

To provide an overview of the current understanding of LOXL2's molecular functions.
To explore proposed roles of LOXL2 in both extracellular and intracellular cell signaling pathways.
To highlight the association of LOXL2 dysregulation with various pathological conditions.

Main Methods:

This review synthesizes existing literature on LOXL2.
It examines proposed biochemical mechanisms of LOXL2.
It correlates LOXL2 function with disease pathogenesis.

Main Results:

LOXL2 plays a role in ECM remodeling through collagen and elastin crosslinking.
LOXL2 is implicated in regulating critical cell signaling pathways.
Aberrant LOXL2 activity is linked to cancer, fibrosis, angiogenesis, and heart diseases.

Conclusions:

LOXL2 is a multifunctional enzyme with significant roles in ECM structure and cell signaling.
Dysregulation of LOXL2 contributes to the development and progression of multiple diseases.
Further research into LOXL2's molecular functions is crucial for understanding and potentially treating these conditions.