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Antihistamine use in children.

Roisin Fitzsimons1, Lauri-Ann van der Poel2, William Thornhill3

  • 1Children's Allergy Service, Guy's and St. Thomas' NHS Foundation Trust, London, UK Department of Asthma, Allergy and Respiratory Science, King's College London, London, UK.

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|August 23, 2014
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Summary

Second-generation antihistamines are recommended for children with allergic conditions due to their superior safety and efficacy compared to first-generation options. This review details antihistamine use, dosing, and indications in pediatric allergy management.

Keywords:
AllergyDermatologyPaediatric PracticeRespiratoryTherapeutics

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Area of Science:

  • Pediatric Allergy and Immunology
  • Pharmacology
  • Clinical Therapeutics

Background:

  • Histamine H(1)-antihistamines are widely used for allergic conditions in children.
  • Understanding histamine receptor pharmacology and drug pharmacokinetics is crucial for effective pediatric dosing.

Purpose of the Study:

  • To review the use of first- and second-generation H(1)-antihistamines in pediatric populations.
  • To provide guidance on the selection and administration of antihistamines for various allergic conditions in children.

Main Methods:

  • Comprehensive literature review of H(1)-antihistamine pharmacology, pharmacokinetics, and clinical applications in children.
  • Analysis of safety profiles, efficacy, and dosing considerations for different antihistamine generations.

Main Results:

  • Second-generation H(1)-antihistamines demonstrate a better safety profile (fewer cognitive and antimuscarinic effects) and longer duration of action than first-generation agents.
  • Second-generation antihistamines are preferred for non-anaphylactic allergic reactions, allergic rhinitis, atopic eczema, and chronic spontaneous urticaria in children.

Conclusions:

  • Second-generation H(1)-antihistamines are the preferred choice for managing common allergic conditions in children.
  • This review offers practical guidance on antihistamine selection, dosing, and administration for pediatric use.