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Updated: Apr 25, 2026

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
Optimization of Rutaecarpine as ABCA1 Up-Regulator for Treating Atherosclerosis
Yongzhen Li1, Tingting Feng1, Peng Liu1
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College , Tiantanxili No. 1, Beijing 100050, China.
Abstract:
ATP-binding cassette transporter A1 (ABCA1) is a key transporter and receptor in promoting cholesterol efflux, and increasing the expression level of ABCA1 is antiatherogenic. In our previous study, rutaecarpine (RUT) was found to protect ApoE(-/-) mice from developing atherosclerosis through preferentially up-regulating ABCA1 expression. In the present work, a series of RUT derivatives were synthesized and examined as ABCA1 expression up-regulators. Compounds CD1, CD6, and BCD1-2 were found to possess the most potential activity as antiatherosclerotic agents among all compounds tested.
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