Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

26
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory...
26
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

12
Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
12
Diabetic Neuropathy01:22

Diabetic Neuropathy

42
DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
42
Diabetic Nephropathy01:28

Diabetic Nephropathy

25
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration...
25
Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

13
Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...
13
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temperature Control After In-Hospital Cardiac Arrest: Outcomes From the Discover In-Hospital Cardiac Arrest Cohort.

Critical care medicine·2026
Same author

Forefoot Charcot Neuroarthropathy following Forefoot Surgery in a Non-Diabetic Patient with Myelopathy: A Rare Presentation not to be Missed.

Journal of orthopaedic case reports·2026
Same author

UV dermoscope used as a Wood's lamp reveals "invisible" pityriasis versicolor.

Journal of the American Academy of Dermatology·2026
Same author

Successful Treatment of Cryptogenic NORSE Resistant to Immunosuppression With Intravenous Ganaxolone and Electroconvulsive Therapy.

The Neurohospitalist·2025
Same author

Endocarditis Associated With Coronary Cameral Fistula Presenting With Intracranial Hemorrhage.

JACC. Case reports·2024
Same author

Noninvasive Ventilation for Preoxygenation during Emergency Intubation.

The New England journal of medicine·2024

Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.4K

Osteomyelitis in the diabetic foot.

Rishi Malhotra1, Claire Shu-Yi Chan1, Aziz Nather1

  • 1Department of Orthopaedics Surgery, National University Health System, Singapore.

Diabetic Foot & Ankle
|August 23, 2014
PubMed
Summary

Diabetic foot osteomyelitis (OM) requires a high index of suspicion. Diagnosis combines clinical signs like exposed bone with imaging studies, guiding effective treatment strategies.

Keywords:
amputationantibioticsdiabetic footinfectionosteomyelitisulcer

More Related Videos

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
09:15

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Published on: October 10, 2017

12.7K

Related Experiment Videos

Last Updated: Apr 25, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.4K
Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model
09:15

Come to the Light Side: In Vivo Monitoring of Pseudomonas aeruginosa Biofilm Infections in Chronic Wounds in a Diabetic Hairless Murine Model

Published on: October 10, 2017

12.7K

Area of Science:

  • Podiatric Medicine
  • Infectious Diseases
  • Radiology

Background:

  • Diabetic foot osteomyelitis (OM) is a frequent complication of diabetic foot ulcers and infections.
  • Early diagnosis and treatment are crucial for limb salvage in diabetic patients.

Purpose of the Study:

  • To review the clinical presentation, diagnostic methods, and treatment options for osteomyelitis in the diabetic foot.
  • To emphasize the importance of integrating clinical findings with imaging for accurate diagnosis.

Main Methods:

  • Literature review of clinical presentation, diagnostic imaging, and treatment modalities for diabetic foot osteomyelitis.
  • Analysis of key diagnostic indicators, including physical examination findings and medical imaging results.

Main Results:

  • Exposed bone within a diabetic foot ulcer is a significant clinical sign suggestive of OM.
  • Diagnostic tools include plain radiographs, magnetic resonance imaging (MRI), and bone scintigraphy.
  • A combination of clinical suspicion, physical examination, and radiological studies is essential for diagnosis.

Conclusions:

  • Accurate diagnosis of diabetic foot osteomyelitis relies on a comprehensive approach.
  • Prompt and appropriate management is vital to prevent severe complications and improve patient outcomes.