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Burn Patients Infected With Metallo-Beta-Lactamase-Producing Pseudomonas aeruginosa: Multidrug-Resistant Strains

Mojtaba Anvarinejad1, Aziz Japoni1, Noroddin Rafaatpour1

  • 1Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran.

Archives of Trauma Research
|August 23, 2014
PubMed
Abstract

Insights

Metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa is a major threat in burn patients. This study identified MDR strains and resistance patterns, highlighting the need for strict antibiotic policies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Burn Care

Background:

  • Metallo-beta-lactamase (MBL) producing Pseudomonas aeruginosa is a significant cause of morbidity and mortality in burn patients.
  • The emergence of multidrug-resistant (MDR) strains poses a serious clinical challenge.

Purpose of the Study:

  • To detect MBL-producing P. aeruginosa in burn patients.
  • To determine the prevalence of MDR strains and their antibiotic resistance patterns.

Main Methods:

  • A cross-sectional study involving 270 P. aeruginosa isolates from burn patients.
  • Identification of 55 MBL-producing P. aeruginosa strains using the E-test method.
  • Determination of Minimum Inhibitory Concentrations (MICs) and MBL presence.

Main Results:

  • Out of 55 burn patients, 17 (30%) expired, with deaths attributed to chemical exposures.
  • Antibiotic susceptibility testing revealed ceftazidime as the most effective agent.
  • A high rate of resistance was observed, with 35 isolates (63.5%) resistant to all 11 tested antibiotics.

Conclusions:

  • Routine microbiological surveillance is crucial for managing burn unit infections.
  • In vitro antibiotic susceptibility testing before prescription is essential.
  • Strict adherence to hospital antibiotic policies can help control MDR and pandrug-resistant (PDR) P. aeruginosa.
Keywords:
Burn patientsDrug ResistanceMetallo-Beta-LactamasePseudomonas aeruginosa

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