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Updated: Apr 25, 2026
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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
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MHC-II: a mutual support system for ILCs and T cells?
Rick M Maizels1, David R Withers2
1Institute of Immunology and Infection Research, and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK.
Immunity
|August 23, 2014
Summary
Group 2 innate lymphoid cells present antigens using MHC class II to regulate immune cells. This interaction is crucial for effective immunity against parasitic worms.
Area of Science:
- Immunology
- Cell Biology
Background:
- Innate and adaptive immune cells collaborate during immune responses.
- The precise mechanisms of this partnership are still being elucidated.
Purpose of the Study:
- To investigate the role of group 2 innate lymphoid cells (ILC2s) in immune regulation.
- To determine the function of MHC class II-peptide presentation by ILC2s.
Main Methods:
- Investigated antigen presentation by ILC2s.
- Assessed the impact on adaptive and innate immune cell populations.
- Evaluated the outcome of antihelminth immunity.
Main Results:
- Group 2 innate lymphoid cells present antigens via MHC class II.
- This presentation is essential for the reciprocal regulation of innate and adaptive immune cells.
- Effective antihelminth immunity requires this ILC2-mediated regulation.
Conclusions:
- MHC class II-peptide presentation by ILC2s is a key mechanism for immune cell crosstalk.
- This pathway is vital for mounting a successful immune response against helminth infections.
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