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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

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Subcutaneous sarcoidosis without systemic involvement.

Jenna L O'Neill¹, Farah Moustafa, Daniel Teague

¹Wake Forest School of Medicine.

Dermatology Online Journal

|August 23, 2014

Summary

Subcutaneous sarcoidosis, a rare skin condition, presents as deep plaques. This case highlights successful treatment with oral prednisone and hydroxychloroquine, even with a family history of pulmonary sarcoidosis.

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Area of Science:

Dermatology
Immunology
Pathology

Background:

Cutaneous sarcoidosis is a multisystem granulomatous disease.
Subcutaneous sarcoidosis is a rare variant characterized by granulomas in the subcutaneous fat.
It typically presents as indurated plaques on the extremities.

Observation:

A middle-aged woman presented with subcutaneous sarcoidosis.
Her work-up for systemic sarcoidosis was negative.
A significant family history revealed a son deceased from pulmonary sarcoidosis complications.

Findings:

The patient's subcutaneous sarcoidosis was successfully treated.
Treatment involved a tapering course of oral prednisone.
Hydroxychloroquine was used in combination with prednisone.

Implications:

Subcutaneous sarcoidosis can occur without systemic involvement.
Combination therapy with prednisone and hydroxychloroquine is effective.
This case contributes to understanding the management of rare sarcoidosis variants.