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RIG-I holds the CARDs in a game of self versus nonself
1Department Biochemistry, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Center for Integrated Protein Sciences, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany; Graduate School for Quantitative Biosciences, Gene Center, Ludwig-Maximilians University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany.
Abstract:
A new study (Wu et al., 2014) employs X-ray crystallography and cryoelectron microscopy (cryo-EM) to reveal how the caspase activation and recruitment domains (CARDs) of the cytosolic viral RNA sensor RIG-I nucleate the formation of large CARD filaments of the mitochondrial antiviral signaling protein MAVS to trigger the antiviral innate immune response.
