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Genetic variants of CD209 associated with Kawasaki disease susceptibility

Ho-Chang Kuo1, Ying-Hsien Huang1, Shu-Chen Chien2

  • 1Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Plos One
|August 23, 2014
PubMed

Insights

Genetic variations in CD209 are linked to Kawasaki disease susceptibility in children. These specific CD209 polymorphisms increase the risk of developing this inflammatory condition.

Area of Science:

  • Immunology
  • Genetics
  • Pediatrics

Background:

  • Kawasaki disease (KD) is a systemic vasculitis of unknown cause, predominantly affecting children in Asian countries.
  • Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN, CD209) plays a role in anti-inflammatory responses and is associated with KD susceptibility.

Purpose of the Study:

  • To investigate the association between genetic polymorphisms of CD209 and the risk of developing Kawasaki disease.
  • To determine if CD209 polymorphisms influence coronary artery lesion formation or treatment response to intravenous immunoglobulin (IVIG).

Main Methods:

  • A total of 948 participants (381 KD patients, 567 controls) were analyzed.
  • Nine tagging single nucleotide polymorphisms (SNPs) in the CD209 gene were genotyped using TaqMan allelic discrimination assays.
  • Clinical data, including coronary artery lesions (CAL) and IVIG treatment outcomes, were collected.

Main Results:

  • Significant associations were identified between specific CD209 polymorphisms (rs4804800, rs2287886, rs735240) and the risk of KD.
  • Haplotype analysis revealed that A/A/G and G/A/G haplotypes in rs2287886/rs735239/rs735240 were associated with an increased risk of KD.
  • No significant associations were found between CD209 polymorphisms and CAL formation or IVIG treatment responsiveness.

Conclusions:

  • CD209 gene polymorphisms are associated with susceptibility to Kawasaki disease.
  • These genetic variations do not appear to influence the risk of coronary artery lesion formation or the effectiveness of IVIG treatment in KD patients.
Abstract

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