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Viral Recombination00:57

Viral Recombination

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Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
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Evaluation of a Universal Nested Reverse Transcription Polymerase Chain Reaction for the Detection of Lyssaviruses
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Novel circovirus from mink, China.

Hai Lian, Ye Liu, Nan Li

    Emerging Infectious Diseases
    |August 23, 2014
    PubMed
    Summary

    A novel circovirus causing enteritis in mink has been identified. This previously unknown virus represents a new species within the Circovirus genus, distinct from parvovirus.

    Area of Science:

    • Veterinary Virology
    • Animal Pathology

    Background:

    • A persistent epidemic of enteritis affecting mink has been documented.
    • The causative agent of this epidemic was previously unidentified and distinct from parvovirus.

    Purpose of the Study:

    • To identify the pathogen responsible for the enteritis epidemic in mink.
    • To characterize the novel virus and determine its taxonomic classification.

    Main Methods:

    • Degenerate PCR was employed to detect and amplify viral genetic material.
    • Full genome sequencing was performed on the identified viral isolate.

    Main Results:

    • A novel circovirus was identified in mink exhibiting enteritis.
    • The complete genome of this circovirus was sequenced.

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  • Phylogenetic analysis indicated that this virus represents a new species within the genus Circovirus, substantially differing from known members.
  • Conclusions:

    • A new circovirus species is responsible for the enteritis epidemic in mink.
    • This discovery expands our understanding of circovirus diversity and its impact on animal health.