Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothesis: Accept or Fail to Reject?01:17

Hypothesis: Accept or Fail to Reject?

28.9K
The outcome of any hypothesis testing leads to rejecting or not rejecting the null hypothesis. This decision is taken based on the analysis of the data, an appropriate test statistic, an appropriate confidence level, the critical values, and P-values. However, when the evidence suggests that the null hypothesis cannot be rejected, is it right to say, 'Accept' the null hypothesis?
There are two ways to indicate that the null hypothesis is not rejected. 'Accept' the null...
28.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insecticide resistance, the uninvited driver for change: impacts on insecticide discovery.

Pest management science·2026
Same author

Unravelling the novel mode of action of the spinosyn insecticides: A 25 year review.

Pesticide biochemistry and physiology·2025
Same author

Trends in insecticide discovery: A review, analysis and perspective.

Pesticide biochemistry and physiology·2025
Same author

Origins of new modes of action for fungicides, herbicides and insecticides: a review and analysis.

Pest management science·2025
Same author

Spinosyn resistance and cross-resistance - A 25 year review and analysis.

Pesticide biochemistry and physiology·2025
Same author

Celebrating Fifty Years of AGRO and a Fruitful Partnership with JAFC.

Journal of agricultural and food chemistry·2024
Same journal

Avermectin disrupts blood-brain barrier integrity in zebrafish larvae via the Wnt/β-catenin signaling pathway.

Pesticide biochemistry and physiology·2026
Same journal

Functional and genetic validation for indazapyroxamet as an antagonist of insect TRPV channels.

Pesticide biochemistry and physiology·2026
Same journal

A novel endophytic Penicillium sp. JL76001 and its metabolite sclerotiorin: A multi-target and sustainable strategy for biocontrol of tomato Fusarium wilt.

Pesticide biochemistry and physiology·2026
Same journal

Transcriptomic and physiological evidence for magnolol antifungal activity against fusarium oxysporum f. sp. cubense tropical race 4.

Pesticide biochemistry and physiology·2026
Same journal

RNA interference targeting BxNDUFA2 impairs mitochondrial function and triggers oxidative stress to control pine wood nematode (Bursaphelenchus xylophilus).

Pesticide biochemistry and physiology·2026
Same journal

Synthesis, characterization, and antimicrobial properties of 8-Hydroxyquinoline-based group 4 metal complexes for plant pathogen control.

Pesticide biochemistry and physiology·2026
See all related articles

Related Experiment Video

Updated: Apr 25, 2026

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

8.5K

Insecticide discovery: an evaluation and analysis.

Thomas C Sparks1

  • 1Dow AgroSciences, Discovery Research, 9330 Zionsville Road, Indianapolis, IN 46268, USA.

Pesticide Biochemistry and Physiology
|August 24, 2014
PubMed
Summary
This summary is machine-generated.

New insecticide discovery is declining due to rising costs and fewer companies investing. Insecticide resistance management is crucial for preserving existing and new pest control solutions.

Keywords:
Development costsInsecticide resistance managementPesticide discovery – time neededScreening successVertebrate selectivity ratio

More Related Videos

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
09:32

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

16.5K
Bioassays for Monitoring Insecticide Resistance
06:30

Bioassays for Monitoring Insecticide Resistance

Published on: December 30, 2010

34.3K

Related Experiment Videos

Last Updated: Apr 25, 2026

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies
09:37

Topical Application Bioassay to Quantify Insecticide Toxicity for Mosquitoes and Fruit Flies

Published on: January 19, 2022

8.5K
Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes
09:32

Protocols for Testing the Toxicity of Novel Insecticidal Chemistries to Mosquitoes

Published on: February 13, 2019

16.5K
Bioassays for Monitoring Insecticide Resistance
06:30

Bioassays for Monitoring Insecticide Resistance

Published on: December 30, 2010

34.3K

Area of Science:

  • Agricultural Science
  • Entomology
  • Pesticide Chemistry

Background:

  • Declining number of research-based companies in insecticide discovery since 1960.
  • Increasing costs associated with pesticide discovery and development.
  • Growing need for novel insecticides with improved environmental and toxicological profiles.

Observation:

  • Analysis of insecticide development timelines over the past 60 years.
  • Examination of discovery processes based on external patents, prior internal products, or novel chemistry.
  • Unexpected trends observed in the time required for insecticide development.

Findings:

  • The agrochemical industry has developed more selective insecticides in the last two decades.
  • The building process for insecticides shows varied timelines depending on the discovery approach.
  • Increasing screening requirements for new product development until recently.

Implications:

  • Insecticide resistance management is increasingly vital.
  • Fewer companies are investing in new insecticide development due to high costs.
  • Preservation of current and future insecticides is essential for sustainable agriculture.