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Updated: Apr 25, 2026
Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
Intravital imaging of cytotoxic T lymphocytes
Gaetano Faleo1, Per-Olof Berggren, Antonello Pileggi
1Transplantation Research Laboratory, Department of Surgery, University of California, 513 Parnassus Ave., HSE-520, San Francisco, CA, 94143, USA, Gaetano.Faleo@ucsfmedctr.org.
Abstract:
Intravital imaging approaches are proving to be essential to address new questions to better understand how the immune system operates. These approaches are especially valuable to characterize the complex organization of immune responses in vivo. Here, we examine how to take advantage of the cornea as a natural body window to apply noninvasive imaging techniques to assess cytotoxic T lymphocyte involvement in the immune rejection process in a model of intraocular allogeneic islet transplantation.
