First case report of vancomycin-intermediate sequence type 72 Staphylococcus aureus with nonsusceptibility to...

Area of Science:

• Infectious Diseases
• Microbiology
• Clinical Medicine

Background:

• Sequence type 72 methicillin-resistant Staphylococcus aureus (MRSA) SCCmec type IV (ST72-MRSA-IV) is a prevalent community-acquired MRSA clone in Korea.
• Limited data exists on daptomycin or vancomycin resistance in community-acquired MRSA clones.

Observation:

• A prosthetic graft infection in the aortic arch and mediastinal abscess was caused by ST72-MRSA-IV in a patient with a history of aortic aneurysm repair.
• Initial treatment with vancomycin and rifampicin was unsuccessful, followed by daptomycin administration.
• Linezolid was administered due to fever recurrence, leading to patient recovery and no recurrence for one year.

Findings:

• The infectious agent was identified as vancomycin-intermediate, daptomycin-nonsusceptible, and rifampicin-resistant ST72-MRSA-IV.
• Minimum inhibitory concentration testing confirmed the antibiotic resistance profile.

Implications:

• This case underscores the critical need to understand evolving infectious agent epidemiology and antibiotic resistance risk factors.
• Awareness of such resistant strains is crucial for minimizing their emergence and spread.
• The principles highlighted are applicable across various infectious disease fields.