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Related Experiment Video

Updated: Apr 25, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Reliable assessment of liver function using LiMAx.

Maximilian Jara1, Jan Bednarsch1, Erika Valle1

  • 1Department of General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin -Campus Virchow-Klinikum, Berlin, Germany.

The Journal of Surgical Research
|August 24, 2014
PubMed
Summary

The LiMAx test demonstrates excellent reproducibility for assessing liver function in healthy individuals and surgical patients. General anesthesia does not impact LiMAx test results, confirming its reliability.

Keywords:
Intra-individual repeatabilityLiver functionLiver function testSurgeryWithin-subject repeatability

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Area of Science:

  • Hepatology
  • Medical Diagnostics
  • Surgical Assessment

Background:

  • 13C-liver function breath tests aid in vivo hepatic function assessment.
  • Evaluating test efficacy and repeatability is crucial for clinical adoption.
  • The LiMAx test aims to determine liver function for perioperative management.

Purpose of the Study:

  • Assess the within-subject repeatability of the LiMAx test.
  • Establish a reference range for the LiMAx test in healthy individuals.
  • Evaluate LiMAx test reliability in patients undergoing surgery.

Main Methods:

  • LiMAx test administered via intravenous (13)C-methacetin injection (2 mg/kg).
  • Eighty-six healthy subjects for reference range determination.
  • Repeat testing on 24 subjects and pre/post-operative testing on 21 surgical patients.

Main Results:

  • Normal LiMAx range: 430 ± 86 μg/kg/h; cut-off value: 315 μg/kg/h.
  • Intraclass correlation coefficient (ICC) for repeatability: 0.85 (healthy) and 0.81 (surgical).
  • General anesthesia showed no significant effect on LiMAx test outcomes.

Conclusions:

  • The LiMAx test exhibits excellent reproducibility in individuals with normal liver function.
  • General anesthesia does not influence the results of the LiMAx test.
  • The LiMAx test is a reliable tool for perioperative liver function assessment.