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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

19
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
19
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

903
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
903
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

24
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
24
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

31
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
31
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

23
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
23

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Related Experiment Video

Updated: Apr 25, 2026

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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Pancreatic panniculitis.

Karim Mahawish1, Isoken T Iyasere2

  • 1Department of Elderly Care, Warrington Hospital, Warrington, UK.

BMJ Case Reports
|August 24, 2014
PubMed
Summary
This summary is machine-generated.

A 55-year-old man with joint pain, weight loss, and skin nodules was diagnosed with metastatic pancreatic neuroendocrine carcinoma. This rare cancer spread to the liver, confirmed by biopsy.

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A Simple and Rapid Method for Simultaneous Isolation of Primary Islets and Primary Pancreatic Acinar Cells from Mice
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Area of Science:

  • Oncology
  • Endocrinology
  • Gastroenterology

Background:

  • Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms originating from endocrine cells of the pancreas.
  • Metastatic PNETs can present with diverse clinical manifestations, often mimicking other conditions.
  • Early diagnosis is crucial for effective management and improved patient outcomes.

Observation:

  • A 55-year-old Caucasian male presented with polyarthritis, unintentional weight loss, and multiple painful subcutaneous nodules.
  • Initial laboratory tests revealed abnormal liver function.
  • Abdominal imaging identified liver lesions suspicious for metastases.

Findings:

  • Liver biopsy confirmed the presence of metastatic neuroendocrine carcinoma.
  • The histological findings were consistent with a pancreatic origin, despite the primary tumor not being initially evident.
  • This case highlights the potential for PNETs to metastasize to the liver, presenting with atypical symptoms.

Implications:

  • This case underscores the importance of considering metastatic pancreatic neuroendocrine carcinoma in the differential diagnosis of patients with unexplained polyarthritis, weight loss, and liver metastases.
  • Comprehensive diagnostic workup, including advanced imaging and tissue biopsy, is essential for accurate diagnosis.
  • Further research into the early detection and management of metastatic PNETs is warranted to improve therapeutic strategies and patient prognosis.