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Updated: Apr 25, 2026
Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
Published on: May 16, 2019
Routine use of EmbryoGlue(®) as embryo transfer medium does not improve the ART outcomes
Somayyeh Safari1, Mohammad Hossein Razi, Samira Safari
1Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Bouali Ave, Safaeiyeh, Yazd, Iran.
Purpose:
The aim was to investigate assisted reproductive technology (ART) outcomes after routine use of EmbryoGlue(®) as a human embryo transfer (ET) medium with high concentration of hyaluronan (HA, hyaluronic acid).
Methods:
A cohort of total 229 patients was retrospectively enrolled for the present study. They were subjected for embryo transfer on day 2 either in EmbryoGlue(®) (n = 117) as study group or in conventional ET medium with low concentration of HA as control group (n = 112).
Results:
Patients in the both groups, in regards to the mean level of day 3 FSH, the etiology of infertility, the history of implantation failure and the rate of good quality embryos showed similar characteristics. There were no significant differences between two groups in terms of clinical and ongoing pregnancies, implantation, delivery and live birth rates. In spite of a decreased abortion and increased multiple pregnancy rates in the study group compared to the control group (15.8 vs. 19 % and 20.6 vs. 15.6 respectively), the differences were not statistically significant.
Conclusions:
Routine use of EmbryoGlue(®)as a HA enriched ET medium for cleavage stage embryos does not have advantage to the conventional one for infertile patients undergoing ART.
