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Affective temperaments and neurocognitive functioning in bipolar disorder.
Manuela Russo1, Katie Mahon1, Megan Shanahan1
1Icahn School of Medicine at Mount Sinai, Departments of Psychiatry and Neuroscience, 1 Gustave L Levy Place Box 1230, New York, NY 10029, United States.
Journal of Affective Disorders
|August 25, 2014
Summary
Affective temperaments like cyclothymia and irritability are linked to specific neurocognitive functions in bipolar disorder (BD). This study explores the connection between temperaments and cognition in BD patients and healthy controls.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Patients with bipolar disorder (BD) exhibit higher affective temperament ratings than healthy controls (HCs).
- These temperaments may represent genetic risk factors or endophenotypes for BD, as seen in unaffected relatives.
- The association between affective temperaments and neurocognition in BD remains largely unexplored.
Purpose of the Study:
- To investigate the relationship between affective temperaments and neurocognitive functioning in individuals with BD.
- To compare these associations in patients with BD and HCs.
Main Methods:
- Affective temperaments were assessed using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego, Auto-questionnaire version (TEMPS-A) in 64 BD patients and 109 HCs.
- Neurocognitive performance was evaluated using the MATRICS Consensus Cognitive Battery (MCCB).
- Correlational analyses examined the links between temperaments and cognition within both groups.
Main Results:
- Affective temperaments and neurocognition showed significant correlations.
- In BD patients, higher cyclothymia and irritability scores correlated with enhanced processing speed, working memory, and problem-solving abilities.
- In HCs, elevated irritability was associated with poorer attention and social cognition.
Conclusions:
- Cyclothymic and irritable temperaments are associated with distinct neurocognitive profiles in BD.
- This research offers preliminary insights into the dimensional interplay between temperament and cognition in BD.
- Future research should explore functional outcomes and investigate unaffected relatives to further elucidate these associations.
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