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Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
Human immunodeficiency virus and coinfection with hepatitis B and C
Lindsay A Petty1, Jennifer L Steinbeck1, Kenneth Pursell1
1Department of Infectious Diseases and Global Health, University of Chicago Medical Center, 5841 South Maryland Avenue, MC 5065, Chicago, IL 60637, USA.
Abstract:
In HIV-infected individuals, coinfection with HBV and/or HCV is common because of shared modes of transmission. It is known that HIV accelerates progression of liver disease and results in increased morbidity and mortality associated with viral hepatitis, but it is less clear if viral hepatitis has a direct effect on HIV. Treatment of viral hepatitis improves outcomes and should be considered in all HIV-infected patients. Treatment of HBV without concurrent treatment of HIV is risky because resistance can occur in both viruses if regimens are not carefully chosen.
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