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Related Experiment Videos

Timed oocyte collection in an assisted conception programme using GnRH analogue.

H I Abdalla1, R J Baber, T Leonard

  • 1Lister Fertility and Endocrinology Centre, Lister Hospital, London, UK.

Human Reproduction (Oxford, England)
|November 1, 1989
PubMed
Summary
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Delaying oocyte retrieval (OPU) in assisted conception programs using GnRH analogue and HMG can improve pregnancy rates and cost-effectiveness. This method allows for programmed cycles and flexible scheduling without compromising outcomes.

Area of Science:

  • Reproductive Medicine
  • Infertility Treatment
  • Assisted Reproductive Technologies

Background:

  • Ovarian stimulation protocols are crucial for assisted conception.
  • GnRH analogue and human menopausal gonadotrophins (HMG) offer programmed cycles.
  • Delayed oocyte retrieval (OPU) scheduling is sometimes necessary.

Purpose of the Study:

  • To evaluate the impact of delayed oocyte retrieval on pregnancy rates.
  • To assess the efficacy of GnRH analogue and HMG in programmed cycles.
  • To determine if delaying OPU affects the number of oocytes collected or gametes transferred.

Main Methods:

  • 325 patients underwent 378 cycles of OPU using GnRH analogue and HMG.
  • Cycles were divided into those with normal timing and delayed OPU (≥24 hours).

Related Experiment Videos

  • Treatments included in-vitro fertilization/embryo transfer (IVF/ET) and gamete intra-Fallopian transfer (GIFT).

    • Main Results:

    • Overall pregnancy rate per OPU was 29.5%.
    • Delayed OPU significantly increased pregnancy rates across all subgroups (overall 37.0% vs. 25.7%).
    • Delayed OPU was associated with a higher number of oocytes collected and gametes/embryos transferred.

    Conclusions:

    • Delaying oocyte retrieval in GnRH analogue and HMG stimulated cycles is not detrimental.
    • Delayed OPU can lead to improved pregnancy rates and allows for flexible scheduling.
    • This approach enhances the cost-effectiveness of assisted conception programs.