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Updated: Apr 25, 2026
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
Published on: October 17, 2018
[Micro magnetic sensitive weighted imaging for intracerebral hemorrhage]
Zhongjie Zhou1, Xiaojun Zhao1, Meikui Chen1
1Department of Radiology, Second Affiliated Hospital, Wenzhou Medical College, Wenzhou 325027, China.
Objective:
To detect cerebral microbleeds by susceptibility weighted imaging and explore the relationship between intracerebral hemorrhage, cerebral microbleeds and risk factors of cerebral vascular disease.
Methods:
A retrospective analysis was conducted for 70 patients from August 2012 to June 2013 undergoing susceptibility weighted imaging (SWI). The average age was (68 ± 14) years. Their demographic and clinical profiles were recorded. Conventional magnetic resonance imaging (MRI) and SWI images were performed and images analyzed by an experienced radiologist. The occurrence of infarction, hemorrhage and number of microbleeds were recorded. Then regression analysis with SPSS 13.0 was used to define the relationship between the existence of infarction, hemorrhage and the number of microbleeds.
Results:
There were 0-65 microbleeds in brains on SWI. There were infarction (n = 44) and chronic intracranial hemorrhage (n = 7). The binary Logistic regression analysis showed that intracranial hemorrhage was associated with hyperlipidemia (P = 0.01).Linear regression analysis showed that the number of microbleeds was related with intracranial hemorrhage (P = 0.02).
Conclusion:
Evaluation of microbleeds in brain by SWI may help to assess the possibility of intracranial hemorrhage so as to provides rationales for clinical therapeutics.
