Primary pulmonary synovial sarcoma: a very rare presentation

Area of Science:

• Oncology
• Pathology
• Thoracic Surgery

Background:

• Synovial sarcoma (SS) is a rare mesenchymal tumor, comprising 5-10% of soft tissue sarcomas.
• Primary pulmonary synovial sarcoma is exceptionally rare, often presenting as an incidental finding.

Purpose of the Study:

• To report a rare case of primary pulmonary synovial sarcoma.
• To highlight diagnostic and therapeutic considerations for this uncommon malignancy.

Main Methods:

• Case presentation of an 18-year-old male with a peripheral lung mass.
• Diagnostic imaging (Thorax CT) and histopathological examination (immunohistochemistry).
• Surgical intervention (Left lower lobectomy).

Main Results:

• A 6 × 6.5 cm, oval, well-delineated pleural-based mass was identified in the left lower lobe.
• Immunohistochemistry revealed positivity for cytokeratin, epithelial membrane antigen (EMA), and vimentin.
• Histopathological diagnosis confirmed biphasic spindle cell type synovial sarcoma.

Conclusions:

• Primary pulmonary synovial sarcoma is a rare entity that requires thorough histopathological evaluation.
• Early diagnosis and surgical resection are crucial for managing pulmonary synovial sarcoma.
• This case underscores the importance of considering rare diagnoses in thoracic oncology.