Science to Practice: Highly shifted proton MR imaging--a shift toward better cell tracking?
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Updated: Apr 25, 2026

Monitoring Dendritic Cell Migration using 19F / 1H Magnetic Resonance Imaging
Published on: March 20, 2013
1Russell H. Morgan Department of Radiology and Radiological Science and Engineering, Division of MR Research, Cellular Imaging Section, Institute for Cell Engineering The Johns Hopkins University School of Medicine 720 Rutland Ave, 217 Traylor Baltimore, MD 21205.
Abstract:
Summary A "hot spot" magnetic resonance (MR) imaging cell tracking technique has been developed that allows direct detection of dysprosium- or thulium-1,4,7,10-tetraazacyclododecane-α,α',α'',α'''-tetramethyl-1,4,7,10-tetraacetic acid (DOTMA)-labeled protons inside cells. These highly shifted protons may allow specific detection of multiple cell types because it does not rely on acquiring the proton signal from bulk water.
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