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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
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IL-17/Th17 pathway is activated in acne lesions
Hanna-Leena Kelhälä1, Riitta Palatsi1, Nanna Fyhrquist2
1Department of Dermatology, University of Oulu and Medical Research Center, Oulu University Hospital, Oulu, Finland.
Plos One
|August 26, 2014
Summary
Inflammation in acne involves the T helper 17 (Th17) pathway, with elevated Interleukin-17 (IL-17) in skin lesions. This suggests Th17 activation plays a key role in acne pathogenesis and may offer new therapeutic targets.
Area of Science:
- Dermatology
- Immunology
- Molecular Biology
Background:
- Acne vulgaris is a common inflammatory skin condition.
- The precise mechanisms of inflammation in acne are under intense investigation.
- Understanding the roles of adaptive and innate immunity is crucial for acne research.
Purpose of the Study:
- To investigate the activation of adaptive and innate immunity in early inflamed acne lesions.
- To identify the specific immune pathways involved in acne pathogenesis.
- To explore potential new therapeutic targets for acne treatment.
Main Methods:
- Biopsies from lesional and non-lesional skin of acne patients were analyzed.
- Gene expression profiling was performed using Affymetrix Genechips.
- Real-time PCR, Luminex technology, and immunohistochemistry were used to validate findings.
Main Results:
- Significant elevation of Th17 signature cytokines, including Interleukin-17 (IL-17), was observed in acne lesions.
- Key cytokines involved in Th17 differentiation (IL-1β, IL-6, TGF-β, IL23p19) were induced.
- Increased numbers of IL-17A positive T cells and CD83 dendritic cells were found in acne lesions.
Conclusions:
- The Th17 pathway is activated in acne lesions, characterized by increased IL-17A positive T cells and related cytokines.
- This activation suggests a pivotal role for the Th17 pathway in acne development.
- Targeting the Th17 pathway may offer novel therapeutic strategies for managing acne.
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