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Related Experiment Videos

Methamphetamine self-administration in humans during D-amphetamine maintenance.

Erika Pike1, William W Stoops, Lon R Hays

  • 1From the Departments of *Behavioral Science, College of Medicine, †Psychology, College of Arts and Sciences, ‡Psychiatry, and §Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, KY.

Journal of Clinical Psychopharmacology
|August 26, 2014
PubMed
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D-amphetamine maintenance did not reduce methamphetamine self-administration in humans, despite attenuating some drug effects and physiological responses. Novel pharmacological treatments are needed for stimulant use disorders.

Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Addiction Medicine

Background:

  • Stimulant use disorders, particularly methamphetamine use disorder, represent a significant public health challenge.
  • Agonist replacement therapy is a potential treatment strategy, but its efficacy for amphetamine-type stimulants requires further investigation.
  • Understanding the interaction between different amphetamines is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate the effects of D-amphetamine maintenance on methamphetamine self-administration in human participants.
  • To determine if D-amphetamine maintenance can reduce the motivation to self-administer methamphetamine.
  • To assess the impact of D-amphetamine on subjective and physiological effects of methamphetamine.

Main Methods:

Related Experiment Videos

  • A within-subject, counterbalanced design was employed with eight participants.
  • Participants received either 0 mg or 40 mg/d of D-amphetamine maintenance.
  • Methamphetamine self-administration was assessed using a progressive-ratio schedule following the sampling of various doses (0, 10, 20, 30 mg).

Main Results:

  • Methamphetamine self-administration increased proportionally with dose, irrespective of D-amphetamine maintenance condition.
  • D-amphetamine maintenance attenuated subjective ratings of drug liking and willingness to take again, among other drug effects.
  • Significant increases in systolic blood pressure induced by methamphetamine were reduced under D-amphetamine maintenance.

Conclusions:

  • D-amphetamine maintenance did not decrease methamphetamine self-administration in this study.
  • While D-amphetamine altered some subjective and physiological responses to methamphetamine, it did not reduce the motivation for self-administration.
  • Current findings suggest that D-amphetamine is not an effective agonist replacement therapy for methamphetamine use disorder, highlighting the need for alternative pharmacological strategies.