Related Experiment Video
Updated: Apr 25, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis
Huixin Liu1, Wenjun Yan, Gaosi Xu
1Medical Center of the Graduate School, Nanchang University , Nanchang , P.R. China and.
Objective:
To assess the efficacy of thyroid hormone replacement therapy for nephrotic syndrome (NS) patients associated with euthyroid sick syndrome (ESS).
Materials And Methods:
The Cochrane library, ISI, Ovid, PubMed, Chinese Biomedicine Database were searched, and reference list of relevant articles were selected. Randomized controlled trials (RCTs) or quasi-RCTs with thyroid hormone replacement on NS patients associated with ESS were included in this analysis.
Results:
Six trials (329 participants) were included. Meta-analysis showed that thyroid hormone replacement therapy can significantly increase the completely remission rate [OR = 3.04, 95% confidence interval (CI): 3.04-1.88, p < 0.00001] and total response rate (OR = 4.63, 95% CI: 2.46-8.71, p < 0.00001) of NS patients associated with ESS. No side effect was observed during the follow-up period. There was no obvious publication bias in the mete-analysis studies.
Conclusions:
Thyroid hormone replacement therapy significantly increases the remission of ESS in patients with NS.
Related Concept Videos
Nephrotic Syndrome III : Nursing Management
Hyperthyroidism I: Introduction
Graves Disease II: Pathophysiology
Hypothyroidism II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Nephrotic Syndrome I : Introduction

