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Hepatitis B core antibody-positive donors in cardiac transplantation: a single-center experience

J L Horan1, J E Stout, B D Alexander

  • 1Department of Medicine/Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.

Transplant Infectious Disease : an Official Journal of the Transplantation Society
|August 27, 2014
PubMed

Insights

Hepatitis B core antibody (HBcAb)-positive donors are safe for heart transplants. A study found no HBV transmission in recipients from 18 HBcAb-positive donors, even with low viral DNA levels.

Area of Science:

  • Transplantation immunology
  • Virology
  • Infectious diseases

Background:

  • Hepatitis B core antibody (HBcAb)-positive donors are increasingly used in organ transplantation.
  • Assessing the risk of Hepatitis B virus (HBV) transmission from these donors is crucial.

Purpose of the Study:

  • To evaluate the safety and outcomes of using HBcAb-positive donors in cardiac transplantation.
  • To determine the incidence of donor-derived HBV transmission in heart transplant recipients.

Main Methods:

  • Retrospective analysis of a single center's experience.
  • Inclusion of 18 cardiac allografts from HBcAb-positive donors.
  • Review of recipient follow-up data, including cases with detectable HBV DNA in donor serum.

Main Results:

  • No documented cases of donor-derived HBV transmission were observed in recipients.
  • This finding held true even for two donors with low-level serum HBV DNA at the time of transplantation.
  • Allograft function and patient survival data were not detailed but the primary outcome of transmission was negative.

Conclusions:

  • Cardiac transplantation using HBcAb-positive donors, even those with low HBV DNA, appears safe regarding HBV transmission.
  • This study supports the continued utilization of HBcAb-positive donors in heart transplantation programs.
  • Further research may explore long-term outcomes and risk stratification in this donor population.

Keywords:
cardiac transplantationdonor-derived infectionshepatitis B virus

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