Related Experiment Video
Updated: Apr 25, 2026
03:47
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
1.6K
Rosacea: new and emerging treatments
Farah A Moustafa1, Laura F Sandoval, Steven R Feldman
1Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.
Drugs
|August 27, 2014
Summary
New treatments for rosacea, a chronic skin condition, show promise. While some therapies like brimonidine tartrate and topical ivermectin are effective, more research is needed to confirm their long-term safety and efficacy.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Rosacea is a chronic inflammatory skin condition impacting patient quality of life.
- Understanding rosacea pathogenesis is crucial for effective management.
- Current treatment options have limitations, necessitating novel therapeutic strategies.
Purpose of the Study:
- To review key aspects of rosacea pathogenesis.
- To evaluate the role of emerging treatments in rosacea management.
- To identify gaps in evidence for new rosacea therapies.
Main Methods:
- Literature review of pathogenesis and treatment of rosacea.
- Analysis of randomized controlled trials (RCTs) and case reports for new treatments.
- Assessment of emerging therapies including brimonidine tartrate, oxymetazoline, and ivermectin.
Main Results:
- Brimonidine tartrate is approved for erythematotelangiectatic rosacea.
- Topical oxymetazoline shows potential for erythematotelangiectatic rosacea, with ongoing RCTs.
- Topical and oral ivermectin demonstrate benefit for papulopustular rosacea, with topical ivermectin 1% cream studied in RCTs.
Conclusions:
- Emerging treatments for rosacea offer promising therapeutic avenues.
- High-quality RCTs are lacking for many new rosacea drugs.
- Further research is essential to establish long-term safety and efficacy of novel interventions.
Related Concept Videos
01:27Acne Infection
89
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
89
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
2.5K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
2.5K
01:23Antidepressant Drugs: MAOIs and Other Agents
1.3K
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.3K
01:26Peptic Ulcer Disease IV: Management
798
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
798
02:56Treatment Resistent Cancers
1.1K
1.1K
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
611
Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
611