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Updated: Apr 25, 2026
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Hospitalisation, surgical and medical recurrence rates in inflammatory bowel disease 2003-2011—a Danish
Marianne K Vester-Andersen1, Ida Vind1, Michelle V Prosberg1
1Gastrounit, Medical Section, Hvidovre Hospital, Hvidovre, University of Copenhagen, Denmark.
Insights
Recurrence rates for Crohn's disease (CD) have decreased, but not for ulcerative colitis (UC), despite improved treatments. Phenotypic characteristics at diagnosis predict recurrence and hospitalization risk in inflammatory bowel disease (IBD).
Area of Science:
- Gastroenterology
- Epidemiology
- Clinical Medicine
Background:
- Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), affects a significant population.
- Understanding recurrence and admission rates is crucial for managing IBD progression and healthcare resource allocation.
Purpose of the Study:
- To evaluate the cumulative probability of recurrence and hospital admission rates in an IBD inception cohort diagnosed between 2003 and 2004.
- To identify predictors of recurrence and hospitalisation based on baseline factors and medication use.
Main Methods:
- Retrospective analysis of 513 IBD patients (300 UC, 213 CD) using medical records and health administrative data.
- Estimation of cumulative recurrence and admission rates, with statistical testing for associations with baseline characteristics and treatments.
Main Results:
- Cumulative risk of first recurrence at 7 years was 66% for CD and 79% for UC. Cumulative surgical relapse risk at 7 years was 23% for CD.
- Hospitalisation rates decreased significantly over 5 years for both CD and UC patients.
- Predictors for CD recurrence included age >40, smoking, stricturing behavior, and colonic/ileocolonic/upper-GI localization. UC recurrence predictors were age >40 and former smoking; left-sided/extensive colitis predicted first hospitalization.
Conclusions:
- Recurrence rates have decreased for CD but not UC, despite advances in treatment.
- Phenotypic characteristics at diagnosis are significant predictors of recurrence and hospitalisation risk in IBD patients.
Objective:
The aim of this study is to evaluate the cumulative probability of recurrence and admission rates in an inflammatory bowel disease (IBD) inception cohort diagnosed in 2003-2004.
Methods:
Data on medications, phenotypes and surgery for 513 individuals with ulcerative colitis (UC, n=300) and Crohn's disease (CD, n=213) were obtained from medical records and linked to population-based health administrative database information. The admission rates and cumulative probability of recurrences were estimated, and the association with the baseline factors and medication was tested.
Results:
The cumulative risk of first recurrence after 1, 5 and 7 years was 40%, 63%, and 66% in CD patients and 51%, 75%, and 79% in UC patients, respectively. The cumulative risk of first surgical relapse was 6%, 18%, and 23% at 1, 5 and 7 years in CD respectively. One hundred and CD patients (66%) and 142 UC patients (47%) had at least one IBD-related hospitalisation. The hospitalisation rate decreased from 7.0 days/person-year in year one to 0.9 day at year 5 in CD, and from 4.7 days to 0.4 days for UC patients. Age above 40, current smoking, stricturing behaviour, and disease localisation (colonic, ileocolonic, and upper-GI) at diagnosis were predictors of recurrence in CD. In UC, age above 40 and former smoker status were predictors of recurrence and left-sided and extensive colitis were predictors of first-time hospitalisation.
Conclusion:
In an era of improved treatment options, the recurrence rates, but not the surgery or hospitalisation rates, have decreased for CD but not for UC. The phenotypic characteristics at diagnosis predict the risk of recurrence and hospitalisation.
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