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Published on: June 2, 2014
[Primary headache associated with sexual activity: 15 new cases and therapeutic outcomes]
Yan Huang1, Kaiyun Zhu2, Junpao Chen
1Department of Neurology,Guangdong No.2 Provincial People's Hospital, Guangzhou 510317, China.
Objective:
To explore the clinical manifestations, diagnosis, treatment and prognostic features of primary headache associated with sexual activity (PHASA) .
Methods:
Fifteen patients were prospectively analyzed over the past 7 years at our hospital. There were 11 males and 4 females with a mean age of (42 ± 11) (26-56) years.
Results:
Their mean ages of onset were 38 ± 7 (26-44) years. For preemptive therapy, 8 patients had received indomethacin (25-50 mg, 30-60 min prior to sexual activity). Among them, 7 patients reported good outcomes and there was one case of limited success. Four patients received sumatriptan (50-100 mg, 30-60 min prior to sexual activity). And 2 patients reported good outcomes and the remaining 2 had no response. They received ibuprofen for preemptive therapy with a complete success. Prophylactic treatment of propranolol 60 mg was indicated for 8 patients. The outcomes were good (n = 6) and non-successful (n = 0). Among 4 patients with a prophylaxis of nimodipine, there were successful (n = 2) and non-successful (n = 2).
Conclusion:
The first-line option for PHASA should be indomethacin. Other drugs may be used for preemptive therapy if there is no relief or adverse effects are intolerable.
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