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Related Experiment Videos

C-reactive protein in acute renal failure.

N A Harrison1, R G Masterton, J M Bateman

  • 1Renal Unit, Princess Mary's Royal Air Force Hospital Halton, Aylesbury, Buckinghamshire, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1989
PubMed
Summary

C-reactive protein (CRP) aids in diagnosing infections in acute renal failure patients. Daily CRP testing using plasma is recommended for early infection detection in these critically ill individuals.

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Area of Science:

  • Clinical Chemistry
  • Nephrology
  • Infectious Diseases

Background:

  • Infection is a primary cause of mortality in critically ill patients with acute renal failure.
  • Early and accurate diagnosis of infection is challenging in this patient population.
  • C-reactive protein (CRP) is a potential biomarker for infection detection.

Observation:

  • C-reactive protein (CRP) can be reliably measured in plasma, circumventing issues associated with serum microclots in heparinized patients.
  • Plasma CRP levels remain stable during hemodialysis, making it suitable for patients undergoing renal replacement therapy.
  • Data from 20 patients with acute renal failure illustrate the utility of CRP in identifying infections.

Findings:

  • C-reactive protein (CRP) assay is effective for diagnosing infections in patients with acute renal failure.

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  • Plasma is a suitable matrix for CRP measurement, offering advantages over serum.
  • CRP levels are not affected by hemodialysis.

    • Implications:

    • Daily monitoring of C-reactive protein (CRP) can significantly improve the early detection of infections in acute renal failure patients.
    • Implementing routine CRP testing can aid clinicians in timely and appropriate management of infections.
    • This approach may lead to improved patient outcomes and reduced mortality in this vulnerable group.