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Myocardial infarction after taking eletriptan.

Andre Dias1, Emiliana Franco2, Kathy Hebert3

  • 1Western Connecticut Health Network, Danbury, CT, United States; Einstein Medical Center, Department of Cardiology, and Jefferson Medical College, Philadelphia, PA, United States.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
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PubMed
Summary

Eletriptan, used for migraines, may cause myocardial infarction even in patients without coronary artery disease. This case highlights a potential risk associated with this migraine medication.

Keywords:
Acute myocardial infarctionCoronary vasospasmEletriptanEletriptanoEnfarte agudo do miocárdioVasoespasmo coronário

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Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Migraine headaches are often treated with triptans, a class of drugs that constrict blood vessels.
  • Eletriptan is a selective serotonin receptor agonist used for acute migraine treatment.
  • Coronary artery disease is a known risk factor for myocardial infarction.

Observation:

  • A 53-year-old male with a history of paroxysmal atrial fibrillation, migraines with visual aura, and non-obstructive coronary artery disease presented with myocardial infarction.
  • The patient had taken eletriptan for migraine relief shortly before symptom onset.

Findings:

  • The myocardial infarction occurred within hours of eletriptan administration.
  • This is the first reported case of myocardial infarction linked to eletriptan in a patient without obstructive coronary artery disease.

Implications:

  • This case suggests a potential causal link between eletriptan use and myocardial infarction, even in individuals without pre-existing coronary artery disease.
  • Further research is warranted to explore the cardiovascular risks associated with eletriptan and other triptans.
  • Clinicians should carefully consider patient history, including cardiovascular risk factors, when prescribing eletriptan for migraine treatment.