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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Related Experiment Video

Updated: Apr 25, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Keratoconus and granular dystrophy.

Clare M Wilson1, Penny J D'Ath2, Dipak N Parmar3

  • 1Department of Visual Neuroscience, UCL Institute of Ophthalmology, London, UK Department of Ophthalmology, Whipps Cross University Hospital, Barts Health, London, UK.

BMJ Case Reports
|August 27, 2014
PubMed
Summary

This case report details a 32-year-old patient experiencing decreased vision due to co-occurring bilateral keratoconus and granular dystrophy. Treatment with contact lenses proved unsuccessful, prompting further investigation into the conditions

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Area of Science:

  • Ophthalmology
  • Genetics

Background:

  • Keratoconus is a progressive thinning of the cornea.
  • Granular dystrophy is a hereditary corneal disease.

Observation:

  • A 32-year-old patient presented with concurrent bilateral keratoconus and granular dystrophy.
  • Vision impairment was the primary symptom.

Findings:

  • Contact lens treatment was attempted but unsuccessful for both conditions.
  • The co-occurrence of these distinct corneal pathologies is rare.

Implications:

  • Discusses the possibility of a chance occurrence or a potential genetic link between keratoconus and granular dystrophy.
  • Highlights the challenges in managing combined corneal conditions.