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Updated: Apr 25, 2026

Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Published on: May 11, 2018
Efficient encapsulation of Fe₃O₄ nanoparticles into genetically engineered hepatitis B core virus-like particles
Lihua Shen1, Jun Zhou, Yixiao Wang
1Department of Biomaterials, College of Materials, Xiamen University, Xiamen, 361005, P.R. China.
Abstract:
Self-assembly of viral coating proteins encapsulating functional nanoparticles provides a new class of biomaterials with robust chemical and physical properties for potential applications in functional imaging, and therapeutic or diagnostic agent delivery. Herein, a straightforward method is demonstrated for efficient encapsidation of magnetic nanoparticles into the engineered virus-like particle (VLP) through the affinity of histidine tags for the nickel- nitrilotriacetic acid (NTA) chelate. Monodispersed, uniformly sized, magnetic core-containing VLPs are obtained at high efficiency (>85%) and used as the cellular T2 contrast agents for MR imaging applications thanks to their biocompatibility, higher cellular uptake, as well as higher r2 values.
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