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Updated: Apr 25, 2026

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury
Published on: July 17, 2016
Acute kidney injury in the neonate
Jennifer G Jetton1, David J Askenazi2
1Division of Nephrology, Dialysis and Transplantation, University of Iowa Children's Hospital, 200 Hawkins Drive, 4023 BT, Iowa City, IA 52242, USA.
Abstract:
Critically ill neonates are at risk for acute kidney injury (AKI). AKI has been associated with increased risk of morbidity and mortality in adult and pediatric patients, and increasing evidence suggests a similar association in the neonatal population. This article describes the current AKI definitions (including their limitations), work on novel biomarkers to define AKI, diagnosis and management strategies, long-term outcomes after AKI, and future directions for much-needed research in this important area.
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