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Renal replacement therapy in neonates

Ahmad Kaddourah1, Stuart L Goldstein1

  • 1Center for Acute Care Nephrology, Cincinnati Children's Hospital Medical Center (CCHMC), MLC 7022, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

Clinics in Perinatology
|August 27, 2014
PubMed

Insights

Acute kidney injury (AKI) is rising in infants. Renal replacement therapy is the sole treatment for severe AKI, managing fluid and electrolyte imbalances in neonatal intensive care units.

Area of Science:

  • Pediatric Nephrology
  • Neonatal Intensive Care

Background:

  • Acute kidney injury (AKI) incidence is increasing in neonates and infants.
  • Pharmacologic treatments for AKI remain limited.
  • Renal replacement therapy (RRT) is crucial for managing severe AKI consequences.

Purpose of the Study:

  • To summarize RRT approaches and modalities for infants with AKI.
  • To provide an overview of current RRT practices in neonatal intensive care units (NICUs).

Main Methods:

  • Literature review of RRT in neonatal populations.
  • Synthesis of data on different RRT modalities.
  • Analysis of RRT application in NICU settings.

Main Results:

  • RRT is essential for hemodynamic and metabolic support in infants with AKI.
  • Various RRT modalities exist, each with specific indications.
  • NICUs employ tailored RRT strategies based on patient condition.

Conclusions:

  • RRT is the primary intervention for severe AKI in neonates and infants.
  • Understanding diverse RRT modalities is vital for optimal patient management.
  • Continued research into RRT is needed to improve outcomes in pediatric AKI.

Keywords:
Acute kidney injuryContinuous renal replacement therapyHyperammonemiaNeonatesPeritoneal dialysis

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