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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
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Neonatal polycystic kidney disease.
Priya Verghese1, Yosuke Miyashita2
1Division of Pediatric Nephrology, Department of Pediatrics, Amplatz Children's Hospital, University of Minnesota, 2450 Riverside Avenue, MB 682, Minneapolis, MN 55454, USA.
Clinics in Perinatology
|August 27, 2014
Summary
This review covers neonatal polycystic kidney disease (PKD), detailing hereditary causes like autosomal recessive PKD and autosomal dominant PKD, and nonhereditary conditions such as multicystic dysplastic kidney.
Area of Science:
- Pediatric Nephrology
- Medical Genetics
- Developmental Biology
Background:
- Neonatal polycystic kidney disease (PKD) presents a diagnostic challenge.
- Understanding the diverse etiologies is crucial for appropriate management.
Purpose of the Study:
- To provide a comprehensive review of neonatal polycystic kidney disease (PKD).
- To emphasize differential diagnosis, clinical features, diagnostic methods, and therapeutic strategies for major causes of neonatal PKD.
Main Methods:
- Literature review and synthesis of current knowledge on neonatal PKD.
- Focus on hereditary (autosomal recessive PKD, autosomal dominant PKD) and nonhereditary causes.
- Inclusion of multicystic dysplastic kidney, obstructive cystic dysplasia, and simple/complex cysts.
Main Results:
- Detailed comparison of clinical manifestations and diagnostic findings for various neonatal cystic kidney diseases.
- Summary of current therapeutic approaches for different forms of neonatal PKD.
- Highlighting the importance of accurate differentiation for prognosis and treatment.
Conclusions:
- Accurate diagnosis of neonatal PKD subtypes is essential for guiding management.
- A multidisciplinary approach is often required for optimal patient outcomes.
- Further research into novel therapeutic targets for neonatal cystic kidney diseases is warranted.
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