Evaluation of molecules based on the electron donor-acceptor architecture as near-infrared β-amyloidal-targeting
Hualong Fu1, Mengchao Cui, Peiyu Tu
1Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China. cmc@bnu.edu.cn.
Chemical Communications (Cambridge, England)
|August 27, 2014
Abstract:
A novel class of near-infrared molecules based on the donor-acceptor architecture were synthesized and evaluated as Aβ imaging probes. In vivo imaging studies suggested that MCAAD-3 could penetrate the blood-brain barrier and label Aβ plaques in the brains of transgenic mice. Computational studies could reproduce the experimental trends well.
