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Sleep-related intermittent hypoxemia and glucose intolerance: a community-based study
Sakurako Tanno1, Takeshi Tanigawa2, Isao Saito3
1Department of Public Health, Ehime University Graduate School of Medicine, Toon, Japan; Center of Sleep Medicine, Ehime University Hospital, Toon, Japan.
Sleep-related intermittent hypoxemia, common in sleep-disordered breathing, is linked to impaired glucose metabolism and insulin resistance in Japanese adults. This condition may increase the risk of developing type 2 diabetes.
Area of Science:
- Endocrinology
- Sleep Medicine
- Metabolic Disorders
Background:
- Sleep-disordered breathing frequently causes intermittent hypoxemia, a condition that can disrupt glucose metabolism.
- Understanding the link between sleep-related intermittent hypoxemia and glucose metabolism is crucial for public health.
Purpose of the Study:
- To investigate the association between sleep-related intermittent hypoxemia and glucose metabolism in middle-aged and older Japanese adults.
- To examine the relationship between the oxygen desaturation index (ODI) and glucose intolerance, insulin resistance, and diabetes prevalence.
Main Methods:
- A cohort of 1836 Japanese adults (30-79 years) underwent overnight pulse-oximetry and oral glucose tolerance testing.
- The oxygen desaturation index (ODI) was categorized into normal, mild, and moderate to severe levels.
- Logistic regression analyses assessed the association between ODI and glucose metabolism parameters, including HOMA-IR and Matsuda index.
Main Results:
- Higher ODI levels (≥15.0 events/h) were associated with increased odds of prevalent glucose intolerance (OR 1.69, 1.03-2.76).
- Both HOMA-IR and Matsuda index showed significant associations with the severity of sleep-related intermittent hypoxemia (P for trend = 0.03 and 0.007, respectively).
Conclusions:
- Sleep-related intermittent hypoxemia is significantly associated with glucose intolerance and insulin resistance in middle-aged and older Japanese adults.
- These findings suggest that intermittent hypoxemia may play a role in the development of type 2 diabetes mellitus.
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