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[Antitubercular agents. 45. Antimycobacterial thiohydrazide]
K Waisser1, Z Odlerová, N Houngbedji
1Lehrstuhl für anorganische und organische Chemie, Pharmazeutische Fakultät der Karls-Universität, Hradec Králové, DDR.
Zentralblatt Fur Mikrobiologie
|January 1, 1989
Abstract:
The present paper investigates the activity of thiohydrazides containing a structural fragment of oxalic acid against Mycobacterium tuberculosis and Mycobacterium kansasii. The drugs included heterocyclic compounds as well. All compounds under study show medium activity. The minimal inhibition concentrations against Mycobacterium kansasii are approximately 3 times higher than against Mycobacterium tuberculosis. The most effective aromatic compounds have the RM values (silica gel impregnated with silicon oil-water) in the interval of 2.2-2.6.