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Sustained mild hypergravity reduces spontaneous cardiac baroreflex sensitivity.

Ryo Yanagida1, Yojiro Ogawa1, Kaname Ueda2

  • 1Division of Hygiene, Department of Social Medicine, Nihon University School of Medicine, Tokyo, Japan.

Autonomic Neuroscience : Basic & Clinical
|August 27, 2014
PubMed
Summary

Mild +Gz hypergravity significantly reduces cardiac baroreflex sensitivity in healthy men. This reduction in baroreflex sensitivity may increase the risk of cardiovascular disturbances during hypergravity exposure.

Keywords:
Artificial gravityCardiovascular variabilityCentral hypovolemiaCentrifugeSequence methodSpontaneous cardiac baroreflex sensitivityTransfer function analysis

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Area of Science:

  • Cardiovascular Physiology
  • Human Physiology
  • Aerospace Medicine

Background:

  • Gravitational force exposure, particularly head-to-foot +Gz hypergravity, causes venous pooling and reduces central blood volume.
  • Central hypovolemia is known to impair spontaneous cardiac baroreflex sensitivity.
  • Previous research has not investigated baroreflex sensitivity during sustained mild +Gz hypergravity.

Purpose of the Study:

  • To investigate the effect of mild +Gz hypergravity on spontaneous cardiac baroreflex sensitivity.
  • To test the hypothesis that mild +Gz hypergravity reduces spontaneous cardiac baroreflex sensitivity compared to 1Gz.

Main Methods:

  • 16 healthy men were exposed to 1Gz and 1.5Gz using a short-arm centrifuge.
  • Beat-to-beat arterial blood pressure and R-R interval were recorded.
  • Spontaneous cardiac baroreflex sensitivity was assessed using sequence slope and transfer function gain analysis.

Main Results:

  • All measures of spontaneous cardiac baroreflex sensitivity significantly decreased during 1.5Gz exposure compared to 1Gz.
  • Stroke volume significantly decreased during hypergravity exposure.
  • Systolic arterial pressure variability increased, but R-R interval variability did not increase.

Conclusions:

  • Even mild +Gz hypergravity significantly reduces spontaneous cardiac baroreflex sensitivity.
  • Reduced baroreflex sensitivity during hypergravity may elevate the risk of cardiovascular disturbances.
  • Further research is warranted to understand the implications for individuals exposed to hypergravity environments.