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Elevation of serum B-cell activating factor levels during visceral leishmaniasis

Yasuyuki Goto1, Satoko Omachi2, Chizu Sanjoba2

  • 1Laboratory of Molecular Immunology, Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan aygoto@mail.ecc.u-tokyo.ac.jp.

The American Journal of Tropical Medicine and Hygiene
|August 27, 2014
PubMed

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Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...