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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Ethical Issues01:27

Ethical Issues

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Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
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Ethical issues in stem cell research and therapy.

Nancy Mp King, Jacob Perrin

    Stem Cell Research & Therapy
    |August 27, 2014
    PubMed
    Summary

    Advancements in stem cell research present ethical challenges. Careful consideration of consent, safety, and justice is crucial for responsible translation from bench to bedside.

    Area of Science:

    • Biotechnology and Bioethics
    • Stem Cell Research and Translational Medicine

    Background:

    • Rapid advancements in biotechnology have created significant ethical and policy challenges in stem cell research.
    • Existing ethical frameworks require adaptation to address novel issues arising from stem cell therapies.

    Purpose of the Study:

    • To provide an overview of key ethical and policy issues in stem cell research.
    • To highlight challenges specific to stem cell research and translational medicine.
    • To discuss broader implications for all clinical research.

    Main Methods:

    • Review of bioethics and scientific literature.
    • Analysis of ethical considerations related to human embryonic stem cells, induced pluripotent stem cells, and other multipotent stem cells.
    • Examination of policy issues including consent, control, and justice.

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    Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
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    Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy
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    Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
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    Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta
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    Isolation and Characterization of Mesenchymal Stromal Cells from Human Umbilical Cord and Fetal Placenta

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    Main Results:

    • New stem cell types and isolation methods raise novel ethical questions beyond the embryo debate.
    • Induced pluripotent stem cells offer promise but require safety validation for clinical trials.
    • Widespread biobanking of various stem cell sources presents opportunities and policy challenges regarding consent and justice.

    Conclusions:

    • Stem cell research necessitates careful application of existing ethical frameworks and consideration of new ethical implications.
    • Ensuring safety, informed consent, and avoiding therapeutic misconception are paramount for responsible translation.
    • Balancing scientific promise with ethical challenges is essential for the advancement of stem cell research and therapy.