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Spatiotemporal T790M heterogeneity in a patient with EGFR-mutant non-small-cell lung cancer

Akito Hata1, Katsuhiro Masago, Nobuyuki Katakami

  • 1Division of Integrated Oncology, Institute of Biomedical Research and Innovation Kobe, Japan Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
|August 27, 2014
PubMed
Abstract

No abstract available in PubMed .

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
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