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Mid-trimester abortion by extraamniotic Emcredil versus normal saline.

B L Zauva1, I Gupta, G I Dhall

  • 1Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

The Australian & New Zealand Journal of Obstetrics & Gynaecology
|August 1, 1989
PubMed
Summary

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Normal saline is a promising, safe, and cost-effective method for inducing mid-trimester abortions. It demonstrated comparable efficacy to Emcredil with fewer complications and side effects.

Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Pharmacology

Background:

  • Mid-trimester abortions require effective and safe induction methods.
  • Evaluating alternative agents for abortion induction is crucial for patient safety and accessibility.

Purpose of the Study:

  • To compare the efficacy and safety of 0.1% Emcredil versus normal saline for extraamniotic induction of mid-trimester abortion.
  • To assess the induction-abortion interval, completeness of abortion, and complication rates between the two agents.

Main Methods:

  • A comparative study involving 40 patients undergoing mid-trimester abortion.
  • Extraamniotic instillation of either 0.1% Emcredil (Group 1, n=20) or normal saline (Group 2, n=20).
  • Comparison of demographic data, induction-abortion interval, abortion completeness, and complications.
Keywords:
Abortion, InducedEvaluationExaminations And DiagnosesFamily PlanningFertility Control, PostconceptionIngredients And ChemicalsLaboratory Examinations And DiagnosesPregnancyPregnancy, Second TrimesterReproductionSaline Solution, Hypertonic

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Main Results:

  • Both groups were comparable in age, parity, and gestational period.
  • Mean induction-abortion intervals were 18 hours 9 minutes (Emcredil) and 19 hours 19 minutes (saline).
  • Complete abortion occurred in 45% of the Emcredil group and 65% of the saline group; no significant complications were reported.

Conclusions:

  • Normal saline is a safe, cost-effective, and promising agent for mid-trimester abortion induction.
  • Saline may induce abortion by damaging decidual cells and locally liberating prostaglandins.
  • The study highlights normal saline as a viable alternative with no contraindications or side-effects.