Pretargeted imaging using bioorthogonal chemistry in mice

Area of Science:

• Chemical biology
• Molecular imaging
• Medical therapy

Background:

• In vivo chemistry applications are expanding from chemical biology to non-invasive imaging and therapy.
• Pretargeted radioimmuno-imaging and -therapy involves antibody-based tumor targeting followed by a radiolabeled probe.
• There is growing interest in applying these techniques in living animals and humans.

Purpose of the Study:

• To review the requirements for advancing in vivo chemistry to non-invasive applications in animals.
• To summarize recent achievements in non-invasive molecular imaging and therapy.
• To provide a perspective on future developments in the field.

Main Methods:

• Review of current literature on in vivo chemistry and pretargeted radioimmuno-imaging/-therapy.
• Analysis of requirements for non-invasive applications in animal models.
• Synthesis of recent advancements and future outlook.

Main Results:

• Successful application of in vivo chemistry in chemical biology.
• Growing interest in extending applications to non-invasive molecular imaging and therapy.
• Development of pretargeted radioimmuno-imaging and -therapy strategies.

Conclusions:

• The field is progressing towards non-invasive applications in animals.
• Further research is needed to meet the requirements for clinical translation.
• Future developments hold promise for improved molecular imaging and therapy.