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Related Concept Videos

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
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Related Experiment Video

Updated: Jul 19, 2026

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

[Metabolic changes and infusion therapy in ileus].

M Sachs1, F Asskali, B Ziegler

  • 1Chirurgische Klinik, Krankenhaus Nordwest, Frankfurt/Main.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|December 1, 1989
PubMed
Summary

Patients with ileus experience metabolic changes, including altered glucose, fat, and protein metabolism. Perioperative nutritional support with fructose, amino acids, and albumin is recommended to address these ileus-related metabolic shifts.

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Last Updated: Jul 19, 2026

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Area of Science:

  • Metabolic changes in ileus
  • Parenteral nutrition
  • Perioperative care

Context:

  • Ileus, a condition of intestinal obstruction, significantly impacts patient metabolism.
  • Understanding these metabolic alterations is crucial for effective perioperative management.
  • Previous research has not fully elucidated the specific metabolic shifts during ileus.

Purpose:

  • To investigate the intermediary metabolic changes associated with mechanical ileus.
  • To develop a pathophysiologically informed strategy for parenteral perioperative nutrition in ileus patients.

Summary:

  • Seventeen patients with mechanical ileus showed typical postaggressive metabolic changes, with elevated preoperative serum albumin, lactate, and arachidonic acid.
  • Postoperatively, significant reductions in glucoplastic amino acids (30%), albumin (40%), pre-albumin (80%), and cholesterol (50%) were observed.
  • Histamine levels remained within normal limits throughout the study.

Impact:

  • Suggests a perioperative nutritional regimen for ileus patients including preoperative fructose and postoperative amino acids and albumin.
  • Highlights the importance of targeted nutritional interventions to mitigate ileus-induced metabolic derangements.
  • Aims to improve patient outcomes through optimized perioperative nutritional support.