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Electrochemistry and analytical determination of lysergic acid diethylamide (LSD) via adsorptive stripping
Daniele Merli1, Daniele Zamboni1, Stefano Protti1
1Dipartimento di Chimica, Università degli Studi di Pavia, 27100 Pavia, Italy.
Abstract:
Lysergic acid diethylamide (LSD) is hardly detectable and quantifiable in biological samples because of its low active dose. Although several analytical tests are available, routine analysis of this drug is rarely performed. In this article, we report a simple and accurate method for the determination of LSD, based on adsorptive stripping voltammetry in DMF/tetrabutylammonium perchlorate, with a linear range of 1-90 ng L(-1) for deposition times of 50s. LOD of 1.4 ng L(-1) and LOQ of 4.3 ng L(-1) were found. The method can be also applied to biological samples after a simple extraction with 1-chlorobutane.
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