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Coronary stenosis dilation by low dose intravenous nitroglycerin
H Sievert1, G Selzer, W Schneider
1Department of Cardiology, University Hospital Frankfurt, F.R.G.
European Heart Journal
|November 1, 1989
Summary
Nitroglycerin dilates coronary artery stenoses in patients with coronary heart disease, suggesting this mechanism contributes to its antianginal effects. Significant hemodynamic changes were not required for these benefits.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Coronary heart disease (CHD) is a leading cause of mortality worldwide.
- Nitroglycerin is a widely used medication for managing angina pectoris, a symptom of CHD.
Purpose of the Study:
- To investigate the effect of intravenous nitroglycerin on coronary artery stenosis diameters in patients with CHD.
- To explore the relationship between coronary artery dilation and the antianginal activity of nitroglycerin.
Main Methods:
- A randomized, double-blind, placebo-controlled study involving 40 patients with CHD.
- Intravenous administration of 0.025 mg nitroglycerin or placebo.
- Measurement of aortic and left ventricular pressures and coronary angiography before and after injection.
Main Results:
- Nitroglycerin significantly increased coronary artery stenosis diameters (P < 0.01).
- No significant changes were observed in heart rate, blood pressure, or left ventricular filling pressure.
- Coronary artery stenosis diameters remained unchanged after placebo administration.
Conclusions:
- Coronary artery stenosis dilation is a key mechanism underlying the antianginal action of nitroglycerin.
- Significant hemodynamic effects are not essential for the beneficial effects of nitroglycerin in CHD patients.
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