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Blood pressure values and depression in hypertensive individuals at high cardiovascular risk
Cilia Mejia-Lancheros, Ramón Estruch, Miguel Angel Martínez-González
1Department of Paediatrics, Obstetrics, Gynaecology and Preventive Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. mamunoz.bcn.ics@gencat.cat.
Insights
Hypertension and depression are linked to cardiovascular disease risk. This study found that hypertensive patients with depression had better blood pressure control, regardless of antidepressant treatment.
Area of Science:
- Cardiology
- Psychiatry
- Public Health
Background:
- Hypertension and depression are significant risk factors for cardiovascular diseases (CVDs).
- The precise relationship between blood pressure control and depression remains incompletely understood.
- This research investigates the influence of depression on blood pressure management in high-risk hypertensive individuals.
Purpose of the Study:
- To determine if depression impacts blood pressure control in hypertensive patients with elevated cardiovascular risk.
- To analyze the association between depression and blood pressure control metrics.
Main Methods:
- A cross-sectional study involving 5954 hypertensive patients with high cardiovascular risk profiles was conducted.
- Data was collected as part of the PREDIMED clinical trial.
- Multivariate regression analyses, including logistic and log-linear models, were employed, adjusting for various confounders.
Main Results:
- Depressive patients, both treated and untreated for depression, exhibited superior blood pressure control compared to non-depressive individuals.
- Systolic blood pressure levels were significantly lower in depressive patients (treated and untreated).
- Odds ratios for better blood pressure control were 1.28 (CI 95%: 1.06-1.55) for treated and 1.30 (CI 95%: 1.03-1.65) for untreated depressive patients.
Conclusions:
- Hypertensive patients at high cardiovascular risk who are diagnosed with depression demonstrate improved blood pressure control.
- Depression may play a role in achieving better blood pressure management in this patient population.
Background:
Hypertension and depression are both important risk factors for cardiovascular diseases. Nevertheless, the association of blood pressure on and depression has not been completely established. This study aims to analyze whether depression may influence the control of blood pressure in hypertensive individuals at high cardiovascular risk.
Methods:
Cross-sectional study, embedded within the PREDIMED clinical trial, of 5954 hypertensive patients with high cardiovascular risk factor profiles. The relationship between blood pressure control and depression was analyzed. A multivariate analysis (logistic and log-linear regression), adjusting for potential confounders (socio-demographic factors, body mass index, lifestyle, diabetes, dyslipidemia, and antihypertensive treatment), was performed.
Results:
Depressive patients, with and without antidepressant treatment, had better blood pressure control (OR: 1.28, CI 95%: 1.06-1.55, and OR: 1.30, CI 95%: 1.03-1.65, respectively) than non-depressive ones. Regarding blood pressure levels, systolic blood pressure values (mmHg) were found to be lower in both treated and untreated depressive patients (Log coefficient Beta: -1.59, 95% CI: -0.50 to -2.69 and Log coefficient Beta: -3.49, 95% CI: -2.10 to -4.87, respectively).
Conclusions:
Among hypertensive patients at high cardiovascular risk, the control of blood pressure was better in those diagnosed with depression.
Trial Registration:
Unique identifier: ISRCTN35739639.
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