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Presynaptic long-term depression mediated by Gi/o-coupled receptors

Brady K Atwood1, David M Lovinger1, Brian N Mathur2

  • 1Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, 5625 Fishers Lane, MSC 9411, Bethesda, MD 20852-9411, USA.

Trends in Neurosciences
|August 28, 2014
PubMed
Summary

Long-term depression (LTD) is crucial for information storage and development. This review focuses on presynaptic LTD mechanisms involving Gi/o-coupled receptors, expanding beyond postsynaptic receptor studies.

Keywords:
G(i/o)-GPCRlong-term synaptic plasticityneurotransmitter releaseplasticity mechanismspresynaptic plasticitysynaptic inhibitionvesicle release machinery

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